CALL FOR PAPERS Metabolic Syndrome Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition
نویسندگان
چکیده
D. S. Gardner, K. Tingey, B. W. M. Van Bon, S. E. Ozanne, V. Wilson, J. Dandrea, D. H. Keisler, T. Stephenson, and M. E. Symonds Centre for Reproduction and Early Life, School of Human Development, University Hospital, Nottingham; Department of Clinical Biochemistry, Addenbrookes Hospital, University of Cambridge, Cambridge; School of Nursing, University of Nottingham, Mansfield, United Kingdom; and Department of Animal Sciences, University of Missouri, Columbia, Missouri
منابع مشابه
Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition.
The present study examines the effects of late vs. early gestation undernutrition on adult glucose-insulin homeostasis in sheep and investigates whether the lower birth weight of twins alters glucose-insulin handling in adult life. Pregnant sheep were fed to requirement (100% intake) from day 0 of gestation to term [ approximately 147 days of gestation (dGA), control singles (CS) n = 5; control...
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Insulin deficiency affects the adult metabolic response to undernutrition, but its effects on the fetal response to maternal undernutrition remain unknown. This study examined the effects of maternal fasting for 48 h in late gestation on the metabolism of fetal sheep made insulin deficient by pancreatectomy (PX). The endocrine and metabolic responses to maternal fasting differed between intact,...
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Lindsey A. George, Liren Zhang, Nuermaimaiti Tuersunjiang, Yan Ma, Nathan M. Long, Adam B. Uthlaut, Derek T. Smith, Peter W. Nathanielsz, and Stephen P. Ford Center for the Study of Fetal Programming, Department of Animal Science, University of Wyoming, Laramie, Wyoming; Kinesiology and Health, University of Wyoming, Laramie, Wyoming; and Center for Pregnancy and Newborn Research, Department of...
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Epidemiological and experimental studies suggest early nutrition has long-term effects on susceptibility to obesity, cardiovascular and metabolic diseases. Small and large animal models confirm the influence of different windows of sensitivity, from fetal to early postnatal life, on offspring phenotype. We showed previously that undernutrition in sheep either during the first month of gestation...
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BACKGROUND Obesity invokes a range of metabolic disturbances, but the transition from a poor to excessive nutritional environment may exacerbate adult metabolic dysfunction. The current study investigated global maternal nutrient restriction during early or late gestation on glucose tolerance and insulin sensitivity in the adult offspring when lean and obese. METHODS/PRINCIPAL FINDINGS Pregna...
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